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【结 构 式】 
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【分子编号】47147 【品名】 【CA登记号】 |
【 分 子 式 】C4H8N3NaO2 【 分 子 量 】153.116308 【元素组成】C 31.38% H 5.27% N 27.44% Na 15.01% O 20.9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Exposure of pyrrolidine (I) to NO in acetonitrile/ether in the presence of NaOMe in MeOH provides sodium 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (II), which is converted into the desired product by reaction with bromomethyl acetate (III) in DMSO in the presence of Na2CO3 and silver acetate (HgOAc).
| 【1】 Saavedra, J.E.; et al.; Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. J Med Chem 1997, 40, 13, 1947. |
| 【2】 Booth, M.N.; Keefer, L.K.; Shami, P.J.; Wang, L.Y.; Saavedra, J.E.; Davies, K.M.; Citro, M.L.; Esterase-sensitive nitric oxide donors of the diazeniumdiolate family: In vitro antileukemic activity. J Med Chem 2000, 43, 2, 261. |
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