|
【结 构 式】 
|
【药物名称】 【化学名称】2-(Acetoxymethoxy)-1-(1-pyrrolidinyl)diazen-1-ium-1-olate 【CA登记号】 【 分 子 式 】C7H13N3O4 【 分 子 量 】203.19936 |
【开发单位】National Cancer Institute (Originator) 【药理作用】Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems, ONCOLYTIC DRUGS, Pharmacological Tools, Apoptosis Inducers, Nitric Oxide Donors |
合成路线1
Exposure of pyrrolidine (I) to NO in acetonitrile/ether in the presence of NaOMe in MeOH provides sodium 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (II), which is converted into the desired product by reaction with bromomethyl acetate (III) in DMSO in the presence of Na2CO3 and silver acetate (HgOAc).
| 【1】 Saavedra, J.E.; et al.; Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. J Med Chem 1997, 40, 13, 1947. |
| 【2】 Booth, M.N.; Keefer, L.K.; Shami, P.J.; Wang, L.Y.; Saavedra, J.E.; Davies, K.M.; Citro, M.L.; Esterase-sensitive nitric oxide donors of the diazeniumdiolate family: In vitro antileukemic activity. J Med Chem 2000, 43, 2, 261. |
Extended Information