ethyl 4-hydroxy-2-(4-morpholinyl)-6-oxo-1,6-dihydro-3-pyridinecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】47075

【品名】ethyl 4-hydroxy-2-(4-morpholinyl)-6-oxo-1,6-dihydro-3-pyridinecarboxylate

【CA登记号】

【分子式】C₁₂H₁₆N₂O₅

【分子量】268.26952

【元素组成】C 53.73% H 6.01% N 10.44% O 29.82%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Cyclization of the diaminoacrylate (I) with bis(2,4,6-trichlorophenyl) malonate (II) in hot toluene produced pyridone (III). This was then condensed with 2,6-dichlorobenzaldehyde (IV) in the presence of piperidine in refluxing EtOH to furnish the title bis-pyridyl derivative.

参考文献中间体

合成目标

【1】 Onnis, V.; Cocco, M.T.; Congiu, C.; Synthesis and antitumor activity of 4-hydroxy-2-pyridone derivatives. Eur J Med Chem 2000, 35, 5, 545.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	47074	ethyl (Z)-3-amino-3-(4-morpholinyl)-2-propenoate		C₉H₁₆N₂O₃	详情	详情
(II)	12956	bis(2,4,6-trichlorophenyl) malonate		C₁₅H₆Cl₆O₄	详情	详情
(III)	47075	ethyl 4-hydroxy-2-(4-morpholinyl)-6-oxo-1,6-dihydro-3-pyridinecarboxylate		C₁₂H₁₆N₂O₅	详情	详情
(IV)	27507	2,6-dichlorobenzaldehyde	83-38-5	C₇H₄Cl₂O	详情	详情

Extended Information