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【结 构 式】 
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【药物名称】 【化学名称】5,5'-[(2,6-Dichlorophenyl)methylene]bis[4-hydroxy-2-(4-morpholinyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid] diethyl ester] 【CA登记号】289896-25-9 【 分 子 式 】C31H34Cl2N4O10 【 分 子 量 】693.54343 |
【开发单位】Università degli Studi di Cagliari (Originator) 【药理作用】Oncolytic Drugs |
合成路线1
Cyclization of the diaminoacrylate (I) with bis(2,4,6-trichlorophenyl) malonate (II) in hot toluene produced pyridone (III). This was then condensed with 2,6-dichlorobenzaldehyde (IV) in the presence of piperidine in refluxing EtOH to furnish the title bis-pyridyl derivative.
| 【1】 Onnis, V.; Cocco, M.T.; Congiu, C.; Synthesis and antitumor activity of 4-hydroxy-2-pyridone derivatives. Eur J Med Chem 2000, 35, 5, 545. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47074 | ethyl (Z)-3-amino-3-(4-morpholinyl)-2-propenoate | C9H16N2O3 | 详情 | 详情 | |
| (II) | 12956 | bis(2,4,6-trichlorophenyl) malonate | C15H6Cl6O4 | 详情 | 详情 | |
| (III) | 47075 | ethyl 4-hydroxy-2-(4-morpholinyl)-6-oxo-1,6-dihydro-3-pyridinecarboxylate | C12H16N2O5 | 详情 | 详情 | |
| (IV) | 27507 | 2,6-dichlorobenzaldehyde | 83-38-5 | C7H4Cl2O | 详情 | 详情 |
Extended Information