合成路线1

Protection of alcohol (I) by means of TBDMSCl in DMF in the presence of imidazole yields compound (II), which is then heated with triethyl orthoformate to afford N-diethoxymethyl-substituted indole (III). Removal of the O-protecting group of (III) by means of tetrabutylammonium fluoride (Bu4NF) in THF provides 2-hydroxy-methylindole derivative (IV), which is converted into the chloro derivative (V) by treatment with CCl4/PPh3 in DMF. (Diethyloxymethyl)-protected indole (V) is then loaded onto 1,2-diol functionalized Merrifield resin (VI) by means of p-TsOH in dioxane to furnish polymer-bound derivative (VII), which is converted into the desired product by first reaction with 1-phenylpiperazine (VIII) in DMF followed by final resin cleavage with HCl/dioxane. Alternatively, the desired compound can be obtained by first conversion of alcohol (I) into chloro derivative (IX) by means of CCl4/PPh3 in DMF, followed by reaction with phenylpiperazine (VIII) in DMF.