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【结 构 式】 
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【分子编号】47030 【品名】2-(chloromethyl)-1-[4-(methoxymethyl)-1,3-dioxolan-2-yl]-1H-indole-5-carbonitrile 【CA登记号】 |
【 分 子 式 】C15H15ClN2O3 【 分 子 量 】306.74848 【元素组成】C 58.73% H 4.93% Cl 11.56% N 9.13% O 15.65% |
合成路线1
该中间体在本合成路线中的序号：(VII)Protection of alcohol (I) by means of TBDMSCl in DMF in the presence of imidazole yields compound (II), which is then heated with triethyl orthoformate to afford N-diethoxymethyl-substituted indole (III). Removal of the O-protecting group of (III) by means of tetrabutylammonium fluoride (Bu4NF) in THF provides 2-hydroxy-methylindole derivative (IV), which is converted into the chloro derivative (V) by treatment with CCl4/PPh3 in DMF. (Diethyloxymethyl)-protected indole (V) is then loaded onto 1,2-diol functionalized Merrifield resin (VI) by means of p-TsOH in dioxane to furnish polymer-bound derivative (VII), which is converted into the desired product by first reaction with 1-phenylpiperazine (VIII) in DMF followed by final resin cleavage with HCl/dioxane. Alternatively, the desired compound can be obtained by first conversion of alcohol (I) into chloro derivative (IX) by means of CCl4/PPh3 in DMF, followed by reaction with phenylpiperazine (VIII) in DMF.
| 【1】 Hubner, H.; Kraxner, J.; Gmeiner, P.; Cyanoindole derivatives as highly selective dopamine D4 receptor partial agonists: Solid-phase synthesis, binding assays, and functional experiments. J Med Chem 2000, 43, 23, 4563. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47025 | 2-(hydroxymethyl)-1H-indole-5-carbonitrile | C10H8N2O | 详情 | 详情 | |
| (II) | 47026 | 2-([[tert-butyl(dimethyl)silyl]oxy]methyl)-1H-indole-5-carbonitrile | C16H22N2OSi | 详情 | 详情 | |
| (III) | 47027 | 2-([[tert-butyl(dimethyl)silyl]oxy]methyl)-1-(diethoxymethyl)-1H-indole-5-carbonitrile | C21H32N2O3Si | 详情 | 详情 | |
| (IV) | 47028 | 1-(diethoxymethyl)-2-(hydroxymethyl)-1H-indole-5-carbonitrile | C15H18N2O3 | 详情 | 详情 | |
| (V) | 47029 | 2-(chloromethyl)-1-(diethoxymethyl)-1H-indole-5-carbonitrile | C15H17ClN2O2 | 详情 | 详情 | |
| (VI) | 47032 | 3-methoxy-1,2-propanediol | C4H10O3 | 详情 | 详情 | |
| (VII) | 47030 | 2-(chloromethyl)-1-[4-(methoxymethyl)-1,3-dioxolan-2-yl]-1H-indole-5-carbonitrile | C15H15ClN2O3 | 详情 | 详情 | |
| (VIII) | 10756 | N-Phenylpiperazine; 1-Phenylpiperazine; Phenyl piperazine | 92-54-6 | C10H14N2 | 详情 | 详情 |
| (IX) | 47031 | 2-(chloromethyl)-1H-indole-5-carbonitrile | C10H7ClN2 | 详情 | 详情 |