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【结 构 式】 
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【分子编号】46857 【品名】2,7,12,17-tetrakis(3-fluoro-4-pyridinyl)-21,22,23,24-tetraazapentacyclo[16.2.1.1(3,6).1(8,11).1(13,16)]tetracosa-1,3,5,7,9,11(23),12,14,16,18(21),19-undecaene 【CA登记号】 |
【 分 子 式 】C40H22F4N8 【 分 子 量 】690.6622128 【元素组成】C 69.56% H 3.21% F 11% N 16.22% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Lithiation of 3-fluoropyridine (I) followed by formylation with methyl formate afforded aldehyde (II). Porphyrin (IV) was then prepared by condensation of aldehyde (II) with pyrrole (III) in refluxing propionic acid. Methylation of (IV) using methyl p-toluenesulfonate then gave the title pyridinium tosylate salt.
| 【1】 Shin, J.-H.; Namgoong, S.K.; Kim, H.-S.; Moon, S.C.; Jeong, B.H.; Lee, B.S.; Yu, B.S.; Lee, J.-S.; Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem Lett 2000, 10, 13, 1435. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 46855 | 3-fluoropyridine | 372-47-4 | C5H4FN | 详情 | 详情 |
| (II) | 46856 | 3-fluoroisonicotinaldehyde | C6H4FNO | 详情 | 详情 | |
| (III) | 21674 | 1H-pyrrole | 109-97-7 | C4H5N | 详情 | 详情 |
| (IV) | 46857 | 2,7,12,17-tetrakis(3-fluoro-4-pyridinyl)-21,22,23,24-tetraazapentacyclo[16.2.1.1(3,6).1(8,11).1(13,16)]tetracosa-1,3,5,7,9,11(23),12,14,16,18(21),19-undecaene | C40H22F4N8 | 详情 | 详情 |
Extended Information