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【结 构 式】 
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【药物名称】 【化学名称】5,10,15,20-Tetrakis(3-fluoro-1-methylpyridinium-4-yl)porphyrin tetra(4-methylbenzenesulfonate) 【CA登记号】 【 分 子 式 】C72H62F4N8O12S4 【 分 子 量 】1435.59294 |
【开发单位】Seoul National University (Originator), Seoul Women's University (Originator), Wonkwang University (Originator) 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, ONCOLYTIC DRUGS, Acetylcholinesterase Inhibitors, Angiogenesis Inhibitors |
合成路线1
Lithiation of 3-fluoropyridine (I) followed by formylation with methyl formate afforded aldehyde (II). Porphyrin (IV) was then prepared by condensation of aldehyde (II) with pyrrole (III) in refluxing propionic acid. Methylation of (IV) using methyl p-toluenesulfonate then gave the title pyridinium tosylate salt.
| 【1】 Shin, J.-H.; Namgoong, S.K.; Kim, H.-S.; Moon, S.C.; Jeong, B.H.; Lee, B.S.; Yu, B.S.; Lee, J.-S.; Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem Lett 2000, 10, 13, 1435. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 46855 | 3-fluoropyridine | 372-47-4 | C5H4FN | 详情 | 详情 |
| (II) | 46856 | 3-fluoroisonicotinaldehyde | C6H4FNO | 详情 | 详情 | |
| (III) | 21674 | 1H-pyrrole | 109-97-7 | C4H5N | 详情 | 详情 |
| (IV) | 46857 | 2,7,12,17-tetrakis(3-fluoro-4-pyridinyl)-21,22,23,24-tetraazapentacyclo[16.2.1.1(3,6).1(8,11).1(13,16)]tetracosa-1,3,5,7,9,11(23),12,14,16,18(21),19-undecaene | C40H22F4N8 | 详情 | 详情 |
Extended Information