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【结 构 式】

【分子编号】46834

【品名】4-(2-bromoethyl)phenol

【CA登记号】

【 分 子 式 】C8H9BrO

【 分 子 量 】201.06286

【元素组成】C 47.79% H 4.51% Br 39.74% O 7.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The condensation of 4-(2-bromoethyl)phenol (I) with ethyl bromoacetate (II) in the presence of K2CO3 produced the phenoxyacetate (III). This was then condensed with (1R,2S)-2-amino-1-(4-hydroxyphenyl)-propan-1-ol (IV) to give adduct (V). the ethyl ester group of (V) was finally hydrolyzed with NaOH to yield the title carboxylic acid.

1 Tamai, T.; Akahane, M.; Mukaiyama, H.; Muranaka, H.; Tanaka, N.; Sato, M.; Hirabayashi, A. (Kissei Pharmaceutical Co., Ltd.); Aminoethylphenoxyacetic acid derivs. and drugs for pain remission and calculi removal promotion in urinary lithiasis. EP 1002791; WO 9905090 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 46834 4-(2-bromoethyl)phenol C8H9BrO 详情 详情
(II) 16640 Ethyl 2-bromoacetate; Ethyl bromoacetate 105-36-2 C4H7BrO2 详情 详情
(III) 46835 ethyl 2-[4-(2-bromoethyl)phenoxy]acetate C12H15BrO3 详情 详情
(IV) 46836 4-[(1R,2S)-2-amino-1-hydroxypropyl]phenol C9H13NO2 详情 详情
(V) 46837 ethyl 2-[4-(2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl)phenoxy]acetate C21H27NO5 详情 详情
Extended Information