[4,7,10-tris(phosphonomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]methylphosphonic acid -Drug Synthesis Database

【结构式】

【分子编号】49689

【品名】[4,7,10-tris(phosphonomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]methylphosphonic acid

【CA登记号】

【分子式】C₁₂H₃₂N₄O₁₂P₄

【分子量】548.300888

【元素组成】C 26.29% H 5.88% N 10.22% O 35.02% P 22.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of 1,4,7,10-tetraazacyclododecane (I) with formaldehyde and phosphoric acid in refluxing aqueous HCl gives the tetraphosphonic acid (II), which is then treated with aqueous 166HoCl3 to obtain the target chelate.

参考文献中间体

合成目标

【1】 Simon, J.; Garlich, J.R.; Wilson, D.A.; McMillan, K. (Marion Merrell Dow, Inc.); Bone marrow suppressing agents. EP 0374501; JP 1990237936; US 4882142 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14855	1,4,7,10-tetraazacyclododecane; Cyclen	294-90-6	C₈H₂₀N₄	详情	详情
(II)	49689	[4,7,10-tris(phosphonomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]methylphosphonic acid		C₁₂H₃₂N₄O₁₂P₄	详情	详情

Extended Information