Holmium-166-DOTMP , 166Ho-DOTMP, -Drug Synthesis Database

【结构式】

【药物名称】Holmium-166-DOTMP , 166Ho-DOTMP

【化学名称】1,1',1'',1'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis(methylphosphonic acid) 166holmium complex

【CA登记号】

【分子式】C₁₂H₃₂HoN₄O₁₂P₄

【分子量】714.30364

【开发单位】International Isotopes (Supplier), Aventis Pharma (Originator), NeoRx (Licensee)

【药理作用】Multiple Myeloma Therapy, Oncolytic Drugs, Radiation Therapy

合成路线1

The reaction of 1,4,7,10-tetraazacyclododecane (I) with formaldehyde and phosphoric acid in refluxing aqueous HCl gives the tetraphosphonic acid (II), which is then treated with aqueous 166HoCl3 to obtain the target chelate.

参考文献中间体

【1】 Simon, J.; Garlich, J.R.; Wilson, D.A.; McMillan, K. (Marion Merrell Dow, Inc.); Bone marrow suppressing agents. EP 0374501; JP 1990237936; US 4882142 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14855	1,4,7,10-tetraazacyclododecane; Cyclen	294-90-6	C₈H₂₀N₄	详情	详情
(II)	49689	[4,7,10-tris(phosphonomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]methylphosphonic acid		C₁₂H₃₂N₄O₁₂P₄	详情	详情

Extended Information