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【结 构 式】 
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【分子编号】49688 【品名】6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-9H-purin-1-ium-1-olate 【CA登记号】 |
【 分 子 式 】C10H13N5O5 【 分 子 量 】283.24392 【元素组成】C 42.41% H 4.63% N 24.73% O 28.24% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Adenosine-N1-oxide (II) was prepared by oxidation of adenosine (I) with meta-chloroperbenzoic acid in MeOH. After alkylation of (II) with 3-methoxybenzyl bromide (III), the resulting compound was treated with ammonium perchlorate to furnish the title perchlorate salt.
| 【1】 Montgomery, J.A.; Secrist, J.A. III; Krauth, C.A. (Southern Research Institute); Adenosine cpds. useful in the prevention and treatment of vaccinia virus infections. US 5102873 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11988 | Adenosine; (2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol | 58-61-7 | C10H13N5O4 | 详情 | 详情 |
| (II) | 49688 | 6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-9H-purin-1-ium-1-olate | C10H13N5O5 | 详情 | 详情 | |
| (III) | 34403 | 1-(bromomethyl)-3-methoxybenzene; 3-(bromomethyl)phenyl methyl ether | C8H9BrO | 详情 | 详情 |
Extended Information