6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-9H-purin-1-ium-1-olate -Drug Synthesis Database

【结构式】

【分子编号】49688

【品名】6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-9H-purin-1-ium-1-olate

【CA登记号】

【分子式】C₁₀H₁₃N₅O₅

【分子量】283.24392

【元素组成】C 42.41% H 4.63% N 24.73% O 28.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Adenosine-N1-oxide (II) was prepared by oxidation of adenosine (I) with meta-chloroperbenzoic acid in MeOH. After alkylation of (II) with 3-methoxybenzyl bromide (III), the resulting compound was treated with ammonium perchlorate to furnish the title perchlorate salt.

参考文献中间体

合成目标

【1】 Montgomery, J.A.; Secrist, J.A. III; Krauth, C.A. (Southern Research Institute); Adenosine cpds. useful in the prevention and treatment of vaccinia virus infections. US 5102873 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11988	Adenosine; (2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol	58-61-7	C₁₀H₁₃N₅O₄	详情	详情
(II)	49688	6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-9H-purin-1-ium-1-olate		C₁₀H₁₃N₅O₅	详情	详情
(III)	34403	1-(bromomethyl)-3-methoxybenzene; 3-(bromomethyl)phenyl methyl ether		C₈H₉BrO	详情	详情

Extended Information