|
【结 构 式】 
|
【药物名称】SRI-7055 【化学名称】1-(3-Methoxybenzyloxy)adenosine perchlorate 【CA登记号】141776-54-7, 123404-14-8 (free base) 【 分 子 式 】C18H22ClN5O10 【 分 子 量 】503.85654 |
【开发单位】Southern Research Institute (Originator), US Army Med. Res. Inst. Infec. Dis. (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antiviral Drugs |
合成路线1
Adenosine-N1-oxide (II) was prepared by oxidation of adenosine (I) with meta-chloroperbenzoic acid in MeOH. After alkylation of (II) with 3-methoxybenzyl bromide (III), the resulting compound was treated with ammonium perchlorate to furnish the title perchlorate salt.
| 【1】 Montgomery, J.A.; Secrist, J.A. III; Krauth, C.A. (Southern Research Institute); Adenosine cpds. useful in the prevention and treatment of vaccinia virus infections. US 5102873 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11988 | Adenosine; (2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol | 58-61-7 | C10H13N5O4 | 详情 | 详情 |
| (II) | 49688 | 6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-9H-purin-1-ium-1-olate | C10H13N5O5 | 详情 | 详情 | |
| (III) | 34403 | 1-(bromomethyl)-3-methoxybenzene; 3-(bromomethyl)phenyl methyl ether | C8H9BrO | 详情 | 详情 |
Extended Information