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【结 构 式】 
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【分子编号】49349 【品名】(1S,2S,3R,4S,7R,9S,11R,13R,16S)-4,13-bis(acetoxy)-16-[((2R,3S)-3-[(tert-butoxycarbonyl)amino]-3-phenyl-2-[[(2,2,2-trichloroethoxy)carbonyl]oxy]propanoyl)oxy]-1-hydroxy-15,18,18-trimethyl-12-oxo-6-oxapentacyclo[12.3.1.0(3,11).0(4,7).0(9,11)]octadec-14-en-2-yl benzoate 【CA登记号】 |
【 分 子 式 】C48H54Cl3NO16 【 分 子 量 】1007.312 【元素组成】C 57.23% H 5.4% Cl 10.56% N 1.39% O 25.41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reaction of the taxoid compound (I) with DAST gives the cyclopropataxoid compound (II), which is finally deprotected with Zn and HOAc to yield the target compound.
| 【1】 Skulnick, H.I.; Johnson, R.A.; Midy, E.G.; Kelly, R.C.; Hester, J.B. Jr. (Pharmacia Corp.); 7-Halo and 7beta,8beta-methano-taxols, antineoplastic use and pharmaceutical compsns. containing them. EP 0674630; WO 9413655 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 49348 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-[((2R,3S)-3-[(tert-butoxycarbonyl)amino]-3-phenyl-2-[[(2,2,2-trichloroethoxy)carbonyl]oxy]propanoyl)oxy]-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C48H56Cl3NO17 | 详情 | 详情 | |
| (II) | 49349 | (1S,2S,3R,4S,7R,9S,11R,13R,16S)-4,13-bis(acetoxy)-16-[((2R,3S)-3-[(tert-butoxycarbonyl)amino]-3-phenyl-2-[[(2,2,2-trichloroethoxy)carbonyl]oxy]propanoyl)oxy]-1-hydroxy-15,18,18-trimethyl-12-oxo-6-oxapentacyclo[12.3.1.0(3,11).0(4,7).0(9,11)]octadec-14-en-2-yl benzoate | C48H54Cl3NO16 | 详情 | 详情 |
Extended Information