【结 构 式】 |
【分子编号】47463 【品名】 【CA登记号】 |
【 分 子 式 】C21H18BrN5O 【 分 子 量 】436.31102 【元素组成】C 57.81% H 4.16% Br 18.31% N 16.05% O 3.67% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The condensation between 3-bromobenzaldehyde (I), 1-(6-morpholinyl-3-pyridinyl)ethanone (II) and malononitrile in the presence of ammonium acetate in refluxing benzene produced the bipyridyl derivative (III). Then treatment of (III) with refluxing formamide gave the title pyridopyrimidine.
【1】 Lee, C.-H.; et al.; Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl) pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J Med Chem 2001, 44, 13, 2133. |
【2】 Cowart, M.D.; Lee, C.-H.; Grillot, A.L.; Bhagwat, S.S.; McKie, J. (Abbott Laboratories Inc.); 5,7-Disubstd.-4-aminopyrido[2,3-d]pyrimidine cpds. and their use as adenosine kinase inhibitors. EP 0989986; WO 9846605 . |
【3】 Stewart, A.O.; Perner, R.J.; McKie, J.A.; Zheng, G.Z.; Grillot, A.L.; Cowart, M.D.; Bhagwat, S.S.; Lee, C.-H. (Abbott Laboratories Inc.); 5,7-Disubstd.-4-aminopyrido[2,3-d]pyrimidine cpds.. WO 0023444 . |
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