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【结 构 式】 
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【药物名称】ABT-702 【化学名称】5-(3-Bromophenyl)-7-[6-(4-morpholinyl)pyridin-3-yl]pyrido[2,3-d]pyrimidin-4-amine 【CA登记号】214697-26-4 【 分 子 式 】C22H19BrN6O 【 分 子 量 】463.34033 |
【开发单位】Abbott (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antiarthritic Drugs, Non-Opioid Analgesics, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Adenosine Kinase Inhibitors |
合成路线1
The condensation between 3-bromobenzaldehyde (I), 1-(6-morpholinyl-3-pyridinyl)ethanone (II) and malononitrile in the presence of ammonium acetate in refluxing benzene produced the bipyridyl derivative (III). Then treatment of (III) with refluxing formamide gave the title pyridopyrimidine.
| 【1】 Lee, C.-H.; et al.; Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl) pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J Med Chem 2001, 44, 13, 2133. |
| 【2】 Cowart, M.D.; Lee, C.-H.; Grillot, A.L.; Bhagwat, S.S.; McKie, J. (Abbott Laboratories Inc.); 5,7-Disubstd.-4-aminopyrido[2,3-d]pyrimidine cpds. and their use as adenosine kinase inhibitors. EP 0989986; WO 9846605 . |
| 【3】 Stewart, A.O.; Perner, R.J.; McKie, J.A.; Zheng, G.Z.; Grillot, A.L.; Cowart, M.D.; Bhagwat, S.S.; Lee, C.-H. (Abbott Laboratories Inc.); 5,7-Disubstd.-4-aminopyrido[2,3-d]pyrimidine cpds.. WO 0023444 . |