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【结 构 式】

【分子编号】46510

【品名】2-[[(E)-1-phenyl-2-(1-pyrrolidinyl)ethenyl]imino]malononitrile

【CA登记号】

【 分 子 式 】C15H14N4

【 分 子 量 】250.30312

【元素组成】C 71.98% H 5.64% N 22.38%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXIII)

In an alternative synthesis, phenylacetaldehyde (XVIII) was condensed with pyrrolidine (XIX) to give enamine (XX). Nitrosation of malononitrile (XXI), followed by treatment with tosyl chloride, produced the O-tosyl oxime (XXII). This was condensed with enamine (XX), and to the intermediate adduct (XXIII) was added thiophenol producing the phenylthiopyrazine (XXIV). Subsequent oxidation of the sulfide group of (XXIV) to sulfone (XXV), followed by condensation with methyl thioglycolate, gave the desired thienopyrazine (XIII).

1 Meyer, M.D.; Altenbach, R.J.; Basha, F.; Carroll, W.A.; Drizin, I.; Kerwin, J.F.; Wendt, M.D.; Haight, A.R.; Zhang, W. (Abbott Laboratories Inc.); Benzopyranopyrrole and benzopyranopyridine alpha-1 adrenergic cpds.. EP 0942911; US 5891882; US 6046207; WO 9824791 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIII) 46503 methyl 7-amino-2-phenylthieno[2,3-b]pyrazine-6-carboxylate C14H11N3O2S 详情 详情
(XVIII) 18456 2-phenylacetaldehyde 122-78-1 C8H8O 详情 详情
(XIX) 11376 Pyrrolidine 123-75-1 C4H9N 详情 详情
(XX) 46508 1-[(E)-2-phenylethenyl]pyrrolidine C12H15N 详情 详情
(XXI) 12061 Malononitrile 109-77-3 C3H2N2 详情 详情
(XXII) 46509 2-([[(4-methylphenyl)sulfonyl]oxy]imino)malononitrile C10H7N3O3S 详情 详情
(XXIII) 46510 2-[[(E)-1-phenyl-2-(1-pyrrolidinyl)ethenyl]imino]malononitrile C15H14N4 详情 详情
(XXIV) 46511 6-phenyl-3-(phenylsulfanyl)-2-pyrazinecarbonitrile C17H11N3S 详情 详情
(XXV) 46512 6-phenyl-3-(phenylsulfonyl)-2-pyrazinecarbonitrile C17H11N3O2S 详情 详情
Extended Information