|
【结 构 式】 
|
【分子编号】46509 【品名】2-([[(4-methylphenyl)sulfonyl]oxy]imino)malononitrile 【CA登记号】 |
【 分 子 式 】C10H7N3O3S 【 分 子 量 】249.25 【元素组成】C 48.19% H 2.83% N 16.86% O 19.26% S 12.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXII)In an alternative synthesis, phenylacetaldehyde (XVIII) was condensed with pyrrolidine (XIX) to give enamine (XX). Nitrosation of malononitrile (XXI), followed by treatment with tosyl chloride, produced the O-tosyl oxime (XXII). This was condensed with enamine (XX), and to the intermediate adduct (XXIII) was added thiophenol producing the phenylthiopyrazine (XXIV). Subsequent oxidation of the sulfide group of (XXIV) to sulfone (XXV), followed by condensation with methyl thioglycolate, gave the desired thienopyrazine (XIII).
| 【1】 Meyer, M.D.; Altenbach, R.J.; Basha, F.; Carroll, W.A.; Drizin, I.; Kerwin, J.F.; Wendt, M.D.; Haight, A.R.; Zhang, W. (Abbott Laboratories Inc.); Benzopyranopyrrole and benzopyranopyridine alpha-1 adrenergic cpds.. EP 0942911; US 5891882; US 6046207; WO 9824791 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIII) | 46503 | methyl 7-amino-2-phenylthieno[2,3-b]pyrazine-6-carboxylate | C14H11N3O2S | 详情 | 详情 | |
| (XVIII) | 18456 | 2-phenylacetaldehyde | 122-78-1 | C8H8O | 详情 | 详情 |
| (XIX) | 11376 | Pyrrolidine | 123-75-1 | C4H9N | 详情 | 详情 |
| (XX) | 46508 | 1-[(E)-2-phenylethenyl]pyrrolidine | C12H15N | 详情 | 详情 | |
| (XXI) | 12061 | Malononitrile | 109-77-3 | C3H2N2 | 详情 | 详情 |
| (XXII) | 46509 | 2-([[(4-methylphenyl)sulfonyl]oxy]imino)malononitrile | C10H7N3O3S | 详情 | 详情 | |
| (XXIII) | 46510 | 2-[[(E)-1-phenyl-2-(1-pyrrolidinyl)ethenyl]imino]malononitrile | C15H14N4 | 详情 | 详情 | |
| (XXIV) | 46511 | 6-phenyl-3-(phenylsulfanyl)-2-pyrazinecarbonitrile | C17H11N3S | 详情 | 详情 | |
| (XXV) | 46512 | 6-phenyl-3-(phenylsulfonyl)-2-pyrazinecarbonitrile | C17H11N3O2S | 详情 | 详情 |
Extended Information