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【结 构 式】 
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【分子编号】46431 【品名】N-(2,6-difluorophenethyl)-1H-imidazole-1-carbothioamide 【CA登记号】 |
【 分 子 式 】C12H11F2N3S 【 分 子 量 】267.3023664 【元素组成】C 53.92% H 4.15% F 14.21% N 15.72% S 12% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)2,6-Difluorophenethylamine (II) was prepared by reduction of nitrile (I) with either NaBH4 in the presence of CoCl2 or borane in THF. Reaction of amine (II) with thiocarbonyldiimidazole (III) furnished the thioimidazolide (IV). This was finally condensed with 2-amino-5-chloropyridine (V), yielding the corresponding thiourea.
| 【1】 Lind, P.T.; Noreen, R.; Ternansky, R.J.; Morin, J.M. Jr. (Medivir AB); Cpds. and methods for inhibition of HIV and related viruses. WO 9303022 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 46429 | 2-(2,6-difluorophenyl)acetonitrile | C8H5F2N | 详情 | 详情 | |
| (II) | 46430 | 2-(2,6-difluorophenyl)-1-ethanamine; 2,6-difluorophenethylamine | C8H9F2N | 详情 | 详情 | |
| (III) | 11990 | Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole | 6160-65-2 | C7H6N4S | 详情 | 详情 |
| (IV) | 46431 | N-(2,6-difluorophenethyl)-1H-imidazole-1-carbothioamide | C12H11F2N3S | 详情 | 详情 | |
| (V) | 18559 | 5-Chloro-2-pyridinylamine; 5-Chloro-2-pyridinamine; 2-Amino-5-chloropyridine | 1072-98-6 | C5H5ClN2 | 详情 | 详情 |
Extended Information