2-(2,6-difluorophenyl)-1-ethanamine; 2,6-difluorophenethylamine -Drug Synthesis Database

【结构式】

【分子编号】46430

【品名】2-(2,6-difluorophenyl)-1-ethanamine; 2,6-difluorophenethylamine

【CA登记号】

【分子式】C₈H₉F₂N

【分子量】157.1630064

【元素组成】C 61.14% H 5.77% F 24.18% N 8.91%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

2,6-Difluorophenethylamine (II) was prepared by reduction of nitrile (I) with either NaBH4 in the presence of CoCl2 or borane in THF. Reaction of amine (II) with thiocarbonyldiimidazole (III) furnished the thioimidazolide (IV). This was finally condensed with 2-amino-5-chloropyridine (V), yielding the corresponding thiourea.

参考文献中间体

合成目标

【1】 Lind, P.T.; Noreen, R.; Ternansky, R.J.; Morin, J.M. Jr. (Medivir AB); Cpds. and methods for inhibition of HIV and related viruses. WO 9303022 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	46429	2-(2,6-difluorophenyl)acetonitrile		C₈H₅F₂N	详情	详情
(II)	46430	2-(2,6-difluorophenyl)-1-ethanamine; 2,6-difluorophenethylamine		C₈H₉F₂N	详情	详情
(III)	11990	Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole	6160-65-2	C₇H₆N₄S	详情	详情
(IV)	46431	N-(2,6-difluorophenethyl)-1H-imidazole-1-carbothioamide		C₁₂H₁₁F₂N₃S	详情	详情
(V)	18559	5-Chloro-2-pyridinylamine; 5-Chloro-2-pyridinamine; 2-Amino-5-chloropyridine	1072-98-6	C₅H₅ClN₂	详情	详情

Extended Information