|
【结 构 式】 
|
【分子编号】46428 【品名】(10R,15S)-15-amino-4-[bis(2-chloroethyl)amino]-10-([[(R)-carboxy(phenyl)methyl]amino]carbonyl)-1-chloro-3-(2-chloroethyl)-4,12-dioxo-5-oxa-8-thia-3,11-diaza-4lambda(5)-phosphahexadecan-16-oic acid 【CA登记号】 |
【 分 子 式 】C26H40Cl4N5O8PS 【 分 子 量 】755.483062 【元素组成】C 41.34% H 5.34% Cl 18.77% N 9.27% O 16.94% P 4.1% S 4.24% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)The known gamma-glutamyl-(S-benzylcysteinyl)-(R)-(-)-phenylglycine (V) was debenzylated to the corresponding thiol (VI) by means of sodium in liquid ammonia. Subsequent S-alkylation of (VI) with bromide (III) produced thioether (VII), which was finally oxidized to the title sulfone employing peracetic acid.
| 【1】 Lyttle, M.H.; et al.; Glutathione-S-transferase activates novel alkylating agents. J Med Chem 1994, 37, 10, 1501. |
| 【2】 Kauvar, L.; Lyttle, M.H.; Satyam, A. (Telik, Inc.); Glutathione S-transferase-activated cpds.. WO 9509866 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 46425 | C10H20BrCl4N2O2P | 详情 | 详情 | ||
| (V) | 46426 | (2S)-2-amino-5-[((1R)-1-[(benzylsulfanyl)methyl]-2-[[(R)-carboxy(phenyl)methyl]amino]-2-oxoethyl)amino]-5-oxopentanoic acid | C23H27N3O6S | 详情 | 详情 | |
| (VI) | 46427 | (2S)-2-amino-5-[[(1R)-2-[[(R)-carboxy(phenyl)methyl]amino]-2-oxo-1-(sulfanylmethyl)ethyl]amino]-5-oxopentanoic acid | C16H21N3O6S | 详情 | 详情 | |
| (VII) | 46428 | (10R,15S)-15-amino-4-[bis(2-chloroethyl)amino]-10-([[(R)-carboxy(phenyl)methyl]amino]carbonyl)-1-chloro-3-(2-chloroethyl)-4,12-dioxo-5-oxa-8-thia-3,11-diaza-4lambda(5)-phosphahexadecan-16-oic acid | C26H40Cl4N5O8PS | 详情 | 详情 |
Extended Information