• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】46426

【品名】(2S)-2-amino-5-[((1R)-1-[(benzylsulfanyl)methyl]-2-[[(R)-carboxy(phenyl)methyl]amino]-2-oxoethyl)amino]-5-oxopentanoic acid

【CA登记号】

【 分 子 式 】C23H27N3O6S

【 分 子 量 】473.55

【元素组成】C 58.34% H 5.75% N 8.87% O 20.27% S 6.77%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The known gamma-glutamyl-(S-benzylcysteinyl)-(R)-(-)-phenylglycine (V) was debenzylated to the corresponding thiol (VI) by means of sodium in liquid ammonia. Subsequent S-alkylation of (VI) with bromide (III) produced thioether (VII), which was finally oxidized to the title sulfone employing peracetic acid.

1 Lyttle, M.H.; et al.; Glutathione-S-transferase activates novel alkylating agents. J Med Chem 1994, 37, 10, 1501.
2 Kauvar, L.; Lyttle, M.H.; Satyam, A. (Telik, Inc.); Glutathione S-transferase-activated cpds.. WO 9509866 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IV) 46425   C10H20BrCl4N2O2P 详情 详情
(V) 46426 (2S)-2-amino-5-[((1R)-1-[(benzylsulfanyl)methyl]-2-[[(R)-carboxy(phenyl)methyl]amino]-2-oxoethyl)amino]-5-oxopentanoic acid C23H27N3O6S 详情 详情
(VI) 46427 (2S)-2-amino-5-[[(1R)-2-[[(R)-carboxy(phenyl)methyl]amino]-2-oxo-1-(sulfanylmethyl)ethyl]amino]-5-oxopentanoic acid C16H21N3O6S 详情 详情
(VII) 46428 (10R,15S)-15-amino-4-[bis(2-chloroethyl)amino]-10-([[(R)-carboxy(phenyl)methyl]amino]carbonyl)-1-chloro-3-(2-chloroethyl)-4,12-dioxo-5-oxa-8-thia-3,11-diaza-4lambda(5)-phosphahexadecan-16-oic acid C26H40Cl4N5O8PS 详情 详情
Extended Information