3-(5-fluoro-2,3-dihydro-1H-inden-2-yl)-1,2-propanediamine; 2-amino-1-[(5-fluoro-2,3-dihydro-1H-inden-2-yl)methyl]ethylamine -Drug Synthesis Database

【结构式】

【分子编号】46418

【品名】3-(5-fluoro-2,3-dihydro-1H-inden-2-yl)-1,2-propanediamine; 2-amino-1-[(5-fluoro-2,3-dihydro-1H-inden-2-yl)methyl]ethylamine

【CA登记号】

【分子式】C₁₂H₁₇FN₂

【分子量】208.2788632

【元素组成】C 69.2% H 8.23% F 9.12% N 13.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

2-(Hydroxymethyl)-5-fluoroindane (I) was converted to bromide (II) upon treatment with CBr4 and PPh3. Alkylation of N-(diphenylmethylene)aminoacetonitrile (III) with bromide (II) under phase-transfer conditions furnished amino nitrile (V), which was reduced to diamine (VI) by using LiAlH4 in THF. Finally, condensation of diamine (V) with formamidine acetate yielded the target imidazoline.

参考文献中间体

合成目标

【1】 Newman-Tancredi, A.; Lacoste, J.-M.; Millan, M.; Cordi, A.; Gobert, A. (ADIR et Cie.); Imidazoline derivs., preparation and pharmaceutical compsns. containing them. EP 1010693; FR 2787451; JP 2000178255; US 6127396 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	46414	(5-fluoro-2,3-dihydro-1H-inden-2-yl)methanol		C₁₀H₁₁FO	详情	详情
(II)	46415	2-(bromomethyl)-5-fluoroindane		C₁₀H₁₀BrF	详情	详情
(III)	46416	2-[(dibenzylene)amino]acetonitrile	70591-20-7	C₁₅H₁₂N₂	详情	详情
(IV)	46417	2-amino-3-(5-fluoro-2,3-dihydro-1H-inden-2-yl)propanenitrile		C₁₂H₁₃FN₂	详情	详情
(V)	46418	3-(5-fluoro-2,3-dihydro-1H-inden-2-yl)-1,2-propanediamine; 2-amino-1-[(5-fluoro-2,3-dihydro-1H-inden-2-yl)methyl]ethylamine		C₁₂H₁₇FN₂	详情	详情

Extended Information