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【结 构 式】 
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【分子编号】46414 【品名】(5-fluoro-2,3-dihydro-1H-inden-2-yl)methanol 【CA登记号】 |
【 分 子 式 】C10H11FO 【 分 子 量 】166.1951432 【元素组成】C 72.27% H 6.67% F 11.43% O 9.63% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)2-(Hydroxymethyl)-5-fluoroindane (I) was converted to bromide (II) upon treatment with CBr4 and PPh3. Alkylation of N-(diphenylmethylene)aminoacetonitrile (III) with bromide (II) under phase-transfer conditions furnished amino nitrile (V), which was reduced to diamine (VI) by using LiAlH4 in THF. Finally, condensation of diamine (V) with formamidine acetate yielded the target imidazoline.
| 【1】 Newman-Tancredi, A.; Lacoste, J.-M.; Millan, M.; Cordi, A.; Gobert, A. (ADIR et Cie.); Imidazoline derivs., preparation and pharmaceutical compsns. containing them. EP 1010693; FR 2787451; JP 2000178255; US 6127396 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 46414 | (5-fluoro-2,3-dihydro-1H-inden-2-yl)methanol | C10H11FO | 详情 | 详情 | |
| (II) | 46415 | 2-(bromomethyl)-5-fluoroindane | C10H10BrF | 详情 | 详情 | |
| (III) | 46416 | 2-[(dibenzylene)amino]acetonitrile | 70591-20-7 | C15H12N2 | 详情 | 详情 |
| (IV) | 46417 | 2-amino-3-(5-fluoro-2,3-dihydro-1H-inden-2-yl)propanenitrile | C12H13FN2 | 详情 | 详情 | |
| (V) | 46418 | 3-(5-fluoro-2,3-dihydro-1H-inden-2-yl)-1,2-propanediamine; 2-amino-1-[(5-fluoro-2,3-dihydro-1H-inden-2-yl)methyl]ethylamine | C12H17FN2 | 详情 | 详情 |
Extended Information