【结 构 式】 |
【分子编号】46291 【品名】4-methylphenethylamine; 2-(4-methylphenyl)-1-ethanamine 【CA登记号】 |
【 分 子 式 】C9H13N 【 分 子 量 】135.20896 【元素组成】C 79.95% H 9.69% N 10.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyldiimidazole (II) afforded the thioimidazolide (III). This was then condensed with 4-methylphenetylamine (IV) in hot DMF to produce the required thiourea.
【2】 Ventalachalam, T.K.; Uckum, F.M. (Parker Hughes Institute); Phenethyl-thiourea cpds. and use. US 6207688 . |
【1】 Uckun, F.M.; Zhu, D.; Pendergrass, S.; Mao, C.; Tuel-Ahlgren, L.; Venkatachalam, T.K.; Maher, D.; N-[2-(4-Methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1. Antivir Chem Chemother 2000, 11, 2, 135. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 12123 | 5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine | 1072-97-5 | C5H5BrN2 | 详情 | 详情 |
(II) | 11990 | Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole | 6160-65-2 | C7H6N4S | 详情 | 详情 |
(III) | 24645 | N-(5-bromo-2-pyridinyl)-1H-imidazole-1-carbothioamide | C9H7BrN4S | 详情 | 详情 | |
(IV) | 46291 | 4-methylphenethylamine; 2-(4-methylphenyl)-1-ethanamine | C9H13N | 详情 | 详情 |
Extended Information