|
【结 构 式】 
|
【药物名称】HI-244 【化学名称】N-(5-Bromopyridin-2-yl)-N'-[2-(4-methylphenyl)ethyl]thiourea 【CA登记号】 【 分 子 式 】C15H16BrN3S 【 分 子 量 】350.28287 |
【开发单位】Parker Hughes Institute (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors |
合成路线1
Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyldiimidazole (II) afforded the thioimidazolide (III). This was then condensed with 4-methylphenetylamine (IV) in hot DMF to produce the required thiourea.
| 【2】 Ventalachalam, T.K.; Uckum, F.M. (Parker Hughes Institute); Phenethyl-thiourea cpds. and use. US 6207688 . |
| 【1】 Uckun, F.M.; Zhu, D.; Pendergrass, S.; Mao, C.; Tuel-Ahlgren, L.; Venkatachalam, T.K.; Maher, D.; N-[2-(4-Methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1. Antivir Chem Chemother 2000, 11, 2, 135. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12123 | 5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine | 1072-97-5 | C5H5BrN2 | 详情 | 详情 |
| (II) | 11990 | Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole | 6160-65-2 | C7H6N4S | 详情 | 详情 |
| (III) | 24645 | N-(5-bromo-2-pyridinyl)-1H-imidazole-1-carbothioamide | C9H7BrN4S | 详情 | 详情 | |
| (IV) | 46291 | 4-methylphenethylamine; 2-(4-methylphenyl)-1-ethanamine | C9H13N | 详情 | 详情 |
Extended Information