tert-butyl (2S)-2-amino-2-phenylethanoate -Drug Synthesis Database

【结构式】

【分子编号】46288

【品名】tert-butyl (2S)-2-amino-2-phenylethanoate

【CA登记号】

【分子式】C₁₂H₁₇NO₂

【分子量】207.27252

【元素组成】C 69.54% H 8.27% N 6.76% O 15.44%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

The reaction of 3,5-difluorophenylacetic acid (I) with oxalyl chloride and DMF in dichloromethane gives the corresponding acyl chloride (II), which is condensed with L-alanine (III) by means of aqueous NaOH, yielding N-(3,5-difluorophenylacetyl)-L-alanine (IV). Finally, this compound is condensed with L-phenylglycine tert-butyl ester (V) by means of 2-ethoxy-1,2-dihydroquinoline-1-carboxylic acid ethyl ester (EEDQ) and NMM in THF.

参考文献中间体

合成目标

【1】 Methods and cpds. for inhibiting beta-amyloid peptide release and/or its synthesis. JP 2001503782; WO 9822494 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28361	2-(3,5-difluorophenyl)acetic acid	105184-38-1	C₈H₆F₂O₂	详情	详情
(II)	28362	2-(3,5-difluorophenyl)acetyl chloride		C₈H₅ClF₂O	详情	详情
(III)	10141	D-Alanine; D-2-Aminopropionic Acid	338-69-2	C₃H₇NO₂	详情	详情
(IV)	46287	(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propionic acid		C₁₁H₁₁F₂NO₃	详情	详情
(V)	46288	tert-butyl (2S)-2-amino-2-phenylethanoate		C₁₂H₁₇NO₂	详情	详情

Extended Information