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【结 构 式】

【分子编号】46288

【品名】tert-butyl (2S)-2-amino-2-phenylethanoate

【CA登记号】

【 分 子 式 】C12H17NO2

【 分 子 量 】207.27252

【元素组成】C 69.54% H 8.27% N 6.76% O 15.44%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The reaction of 3,5-difluorophenylacetic acid (I) with oxalyl chloride and DMF in dichloromethane gives the corresponding acyl chloride (II), which is condensed with L-alanine (III) by means of aqueous NaOH, yielding N-(3,5-difluorophenylacetyl)-L-alanine (IV). Finally, this compound is condensed with L-phenylglycine tert-butyl ester (V) by means of 2-ethoxy-1,2-dihydroquinoline-1-carboxylic acid ethyl ester (EEDQ) and NMM in THF.

1 Methods and cpds. for inhibiting beta-amyloid peptide release and/or its synthesis. JP 2001503782; WO 9822494 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28361 2-(3,5-difluorophenyl)acetic acid 105184-38-1 C8H6F2O2 详情 详情
(II) 28362 2-(3,5-difluorophenyl)acetyl chloride C8H5ClF2O 详情 详情
(III) 10141 D-Alanine; D-2-Aminopropionic Acid 338-69-2 C3H7NO2 详情 详情
(IV) 46287 (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propionic acid C11H11F2NO3 详情 详情
(V) 46288 tert-butyl (2S)-2-amino-2-phenylethanoate C12H17NO2 详情 详情
Extended Information