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【结 构 式】 
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【药物名称】DAPT, LY-374973, AN-37124 【化学名称】N-[2-(3,5-Difluorophenyl)acetyl]-L-alanyl-L-(2-phenyl)glycine tert-butyl ester 【CA登记号】208255-80-5 【 分 子 式 】C23H26F2N2O4 【 分 子 量 】432.47147 |
【开发单位】Elan (Originator), Lilly (Originator) 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Antiamyloidogenic Agents, gamma-Secretase Inhibitors |
合成路线1
The reaction of 3,5-difluorophenylacetic acid (I) with oxalyl chloride and DMF in dichloromethane gives the corresponding acyl chloride (II), which is condensed with L-alanine (III) by means of aqueous NaOH, yielding N-(3,5-difluorophenylacetyl)-L-alanine (IV). Finally, this compound is condensed with L-phenylglycine tert-butyl ester (V) by means of 2-ethoxy-1,2-dihydroquinoline-1-carboxylic acid ethyl ester (EEDQ) and NMM in THF.
| 【1】 Methods and cpds. for inhibiting beta-amyloid peptide release and/or its synthesis. JP 2001503782; WO 9822494 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28361 | 2-(3,5-difluorophenyl)acetic acid | 105184-38-1 | C8H6F2O2 | 详情 | 详情 |
| (II) | 28362 | 2-(3,5-difluorophenyl)acetyl chloride | C8H5ClF2O | 详情 | 详情 | |
| (III) | 10141 | D-Alanine; D-2-Aminopropionic Acid | 338-69-2 | C3H7NO2 | 详情 | 详情 |
| (IV) | 46287 | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propionic acid | C11H11F2NO3 | 详情 | 详情 | |
| (V) | 46288 | tert-butyl (2S)-2-amino-2-phenylethanoate | C12H17NO2 | 详情 | 详情 |