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【结 构 式】 
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【分子编号】46027 【品名】1-(4-benzyl-1-piperazinyl)-1-propanone 【CA登记号】 |
【 分 子 式 】C14H20N2O 【 分 子 量 】232.32568 【元素组成】C 72.38% H 8.68% N 12.06% O 6.89% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Acylation of N-benzylpiperazine (I) with propionyl chloride afforded amide (II). Hydrogenolysis of the N-benzyl protecting group of (II) over Pd/C then gave N-propionyl piperazine (III), which was finally condensed with benzoyl chloride to yield the title diamide.
| 【1】 Galeotti, N.; Gualtiere, F.; Mannetti, D.; Ghelardini, C.; Romanelli, M.N.; Bartolini, A.; Dei, S.; Teodori, E.; Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity. J Med Chem 2000, 43, 23, 4499. |
| 【2】 Bellucci, C.; Ghelardini, C.; Dei, S.; Bartolini, A.; Galeotti, N.; Romanelli, M.N.; Gualtiere, F.; Manetti, D.; Scapecchi, S.; Teodori, E.; 1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs. 16th Int Symp Med Chem (Sept 18 2000, Bologna) 2000, Abst PB-119. |
Extended Information