2,6-di(tert-butyl)-4-([3-[4-(2,3,4-trimethoxybenzyl)-1-piperazinyl]propyl]sulfanyl)phenyl acetate -Drug Synthesis Database

【结构式】

【分子编号】46026

【品名】2,6-di(tert-butyl)-4-([3-[4-(2,3,4-trimethoxybenzyl)-1-piperazinyl]propyl]sulfanyl)phenyl acetate

【CA登记号】

【分子式】C₃₃H₅₀N₂O₅S

【分子量】586.83648

【元素组成】C 67.54% H 8.59% N 4.77% O 13.63% S 5.46%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation between bromide (I) and piperazine (II) in refluxing acetonitrile provided the disubstituted piperazine (III). The acetate ester was then hydrolyzed by means of NaOH to yield the title compound.

参考文献中间体

合成目标

【1】 Regnier, G.; Vilaine, J.-P.; Villeneuve, N.; Bidouard, J.-P.; Iliou, J.-P.; Lenaers, A. (ADIR et Cie.); Trimetazidine derivs., process for their preparation and pharmaceutical compsns. containing them. EP 0533579; FR 2681324; JP 1993194451; US 5283246 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	46025	4-[(3-bromopropyl)sulfanyl]-2,6-di(tert-butyl)phenyl acetate	C₁₉H₂₉BrO₂S	详情	详情
(II)	24354	2,3-dimethoxy-4-(1-piperazinylmethyl)phenyl methyl ether	C₁₄H₂₂N₂O₃	详情	详情
(III)	46026	2,6-di(tert-butyl)-4-([3-[4-(2,3,4-trimethoxybenzyl)-1-piperazinyl]propyl]sulfanyl)phenyl acetate	C₃₃H₅₀N₂O₅S	详情	详情

Extended Information