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【结 构 式】 
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【药物名称】S-151276, S-15176 【化学名称】2,6-Di-tert-butyl-4-[3-[4-(2,3,4-trimethoxybenzyl)-1-piperazinyl]propylsulfanyl]phenol 【CA登记号】148089-70-7, 148913-55-7 (fumarate) 【 分 子 式 】C31H48N2O4S 【 分 子 量 】544.80321 |
【开发单位】Servier (Originator) 【药理作用】GASTROINTESTINAL DRUGS, Hepatoprotectants, Liver and Biliary Tract Disorders, Treatment of, Carnitine O-Palmitoyltransferase 1 (CPT-1) Inhibitors, Free Radical Scavengers, Lipid Peroxidation Inhibitors |
合成路线1
The condensation between bromide (I) and piperazine (II) in refluxing acetonitrile provided the disubstituted piperazine (III). The acetate ester was then hydrolyzed by means of NaOH to yield the title compound.
| 【1】 Regnier, G.; Vilaine, J.-P.; Villeneuve, N.; Bidouard, J.-P.; Iliou, J.-P.; Lenaers, A. (ADIR et Cie.); Trimetazidine derivs., process for their preparation and pharmaceutical compsns. containing them. EP 0533579; FR 2681324; JP 1993194451; US 5283246 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 46025 | 4-[(3-bromopropyl)sulfanyl]-2,6-di(tert-butyl)phenyl acetate | C19H29BrO2S | 详情 | 详情 | |
| (II) | 24354 | 2,3-dimethoxy-4-(1-piperazinylmethyl)phenyl methyl ether | C14H22N2O3 | 详情 | 详情 | |
| (III) | 46026 | 2,6-di(tert-butyl)-4-([3-[4-(2,3,4-trimethoxybenzyl)-1-piperazinyl]propyl]sulfanyl)phenyl acetate | C33H50N2O5S | 详情 | 详情 |
Extended Information