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【结 构 式】 
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【分子编号】45826 【品名】1-[1-(4-fluorophenethyl)-4-piperidinyl]-6-indolinecarbaldehyde 【CA登记号】 |
【 分 子 式 】C22H25FN2O 【 分 子 量 】352.4517832 【元素组成】C 74.97% H 7.15% F 5.39% N 7.95% O 4.54% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XV)Introduction of a formyl group into indoline (X) was carried out via lithiation with n-butyllithium, followed by treatment with dimethylformamide. The resulting aldehyde (XV) was converted to oxime (XVI), which was subsequently reduced to amine (XVII) using LiAlH4. Finally, acylation of amine (XVII) with acetyl chloride produced the title amide.
| 【1】 Kitazawa, N.; Ueno, K.; Sasaki, A.; et al.; Synthesis and evaluation of indoline and indole derivatives as a dual antagonist for 5-HT1A and 5-HT2 receptor. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 97. |
| 【2】 Kimura, T.; Takahashi, K.; Matsunaga, M.; Kawano, K.; Kubota, A.; Kitazawa, N.; Okabe, T.; Ueno, K.; Komatsu, M.; Sasaki, A. (Eisai Co., Ltd.); 1,4-Substd. cyclic amine derivs.. EP 0976732; WO 9843956 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 45822 | 6-bromo-1-[1-(4-fluorophenethyl)-4-piperidinyl]indoline | C21H24BrFN2 | 详情 | 详情 | |
| (XV) | 45826 | 1-[1-(4-fluorophenethyl)-4-piperidinyl]-6-indolinecarbaldehyde | C22H25FN2O | 详情 | 详情 | |
| (XVI) | 45827 | 1-[1-(4-fluorophenethyl)-4-piperidinyl]-6-indolinecarbaldehyde oxime | C22H26FN3O | 详情 | 详情 | |
| (XVII) | 45828 | [1-[1-(4-fluorophenethyl)-4-piperidinyl]-2,3-dihydro-1H-indol-6-yl]methanamine; [1-[1-(4-fluorophenethyl)-4-piperidinyl]-2,3-dihydro-1H-indol-6-yl]methylamine | C22H28FN3 | 详情 | 详情 |
Extended Information