|
【结 构 式】 
|
【分子编号】45615 【品名】 【CA登记号】 |
【 分 子 式 】C21H24O2 【 分 子 量 】308.42036 【元素组成】C 81.78% H 7.84% O 10.38% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Condensation of phenol (I) with acetone (II) in refluxing HOAc/HCl affords diol (III), which is finally converted into the desired compound by first reaction with chlorosulfonic acid in pyridine followed by treatment with aqueous KOH.
| 【1】 Bushman, F.D.; Rubins, K.; Molteni, V.; Hansen, M.; Rhodes, D.; Siegel, J.S.; A new class of HIV-1 integrase inhibitors: The 3,3,3',3'-tetramethyl-1,1'-spirobi (indan)-5',5',6,6'-tetrol family. J Med Chem 2000, 43, 10, 2031. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23540 | Phenol | 108-95-2 | C6H6O | 详情 | 详情 |
| (II) | 23199 | 2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one； Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether | 67-64-1 | C3H6O | 详情 | 详情 |
| (III) | 45615 | C21H24O2 | 详情 | 详情 |
Extended Information