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【结 构 式】 
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【药物名称】 【化学名称】3,3,3',3'-Tetramethyl-1,1'-spirobiindane-6,6'-diol disulfate dipotassium salt 【CA登记号】 【 分 子 式 】C21H22K2O8S2 【 分 子 量 】544.73669 |
【开发单位】Salk Institute for Biological Studies (Originator), University of California, San Diego (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, HIV Integrase Inhibitors |
合成路线1
Condensation of phenol (I) with acetone (II) in refluxing HOAc/HCl affords diol (III), which is finally converted into the desired compound by first reaction with chlorosulfonic acid in pyridine followed by treatment with aqueous KOH.
| 【1】 Bushman, F.D.; Rubins, K.; Molteni, V.; Hansen, M.; Rhodes, D.; Siegel, J.S.; A new class of HIV-1 integrase inhibitors: The 3,3,3',3'-tetramethyl-1,1'-spirobi (indan)-5',5',6,6'-tetrol family. J Med Chem 2000, 43, 10, 2031. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23540 | Phenol | 108-95-2 | C6H6O | 详情 | 详情 |
| (II) | 23199 | 2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one； Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether | 67-64-1 | C3H6O | 详情 | 详情 |
| (III) | 45615 | C21H24O2 | 详情 | 详情 |
Extended Information