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【结 构 式】

【分子编号】45365

【品名】2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)-N,N-dimethylethanethioamide

【CA登记号】

【 分 子 式 】C17H25NO2S

【 分 子 量 】307.45704

【元素组成】C 66.41% H 8.2% N 4.56% O 10.41% S 10.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of 2-(4-methoxyphenyl)-N,N-dimethylthioacetamide (I) with cyclohexanone (II) by means of isopropylmagnesium bromide in toluene/methyl tert-butyl ether gives 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)-N,N-dimethylthioacetamide (III), which is finally desulfurized by means of Raney-nickel in dioxane/acetic acid.

1 Shepard, R.G. (John Wyeth & Brother Ltd.); Preparation of cyclohexanol derivs. and novel thioamide intermediates. US 5043466 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 45364 2-(4-methoxyphenyl)-N,N-dimethylethanethioamide C11H15NOS 详情 详情
(II) 11059 Cyclohexanone 108-94-1 C6H10O 详情 详情
(III) 45365 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)-N,N-dimethylethanethioamide C17H25NO2S 详情 详情
Extended Information