【结 构 式】 |
【分子编号】45365 【品名】2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)-N,N-dimethylethanethioamide 【CA登记号】 |
【 分 子 式 】C17H25NO2S 【 分 子 量 】307.45704 【元素组成】C 66.41% H 8.2% N 4.56% O 10.41% S 10.43% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The condensation of 2-(4-methoxyphenyl)-N,N-dimethylthioacetamide (I) with cyclohexanone (II) by means of isopropylmagnesium bromide in toluene/methyl tert-butyl ether gives 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)-N,N-dimethylthioacetamide (III), which is finally desulfurized by means of Raney-nickel in dioxane/acetic acid.
【1】 Shepard, R.G. (John Wyeth & Brother Ltd.); Preparation of cyclohexanol derivs. and novel thioamide intermediates. US 5043466 . |
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