2-(4-methoxyphenyl)-N,N-dimethylethanethioamide -Drug Synthesis Database

【结构式】

【分子编号】45364

【品名】2-(4-methoxyphenyl)-N,N-dimethylethanethioamide

【CA登记号】

【分子式】C₁₁H₁₅NOS

【分子量】209.31224

【元素组成】C 63.12% H 7.22% N 6.69% O 7.64% S 15.32%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The condensation of 2-(4-methoxyphenyl)-N,N-dimethylthioacetamide (I) with cyclohexanone (II) by means of isopropylmagnesium bromide in toluene/methyl tert-butyl ether gives 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)-N,N-dimethylthioacetamide (III), which is finally desulfurized by means of Raney-nickel in dioxane/acetic acid.

参考文献中间体

合成目标

【1】 Shepard, R.G. (John Wyeth & Brother Ltd.); Preparation of cyclohexanol derivs. and novel thioamide intermediates. US 5043466 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	45364	2-(4-methoxyphenyl)-N,N-dimethylethanethioamide		C₁₁H₁₅NOS	详情	详情
(II)	11059	Cyclohexanone	108-94-1	C₆H₁₀O	详情	详情
(III)	45365	2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)-N,N-dimethylethanethioamide		C₁₇H₂₅NO₂S	详情	详情

Extended Information