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【结 构 式】

【分子编号】45316

【品名】1-fluoro-4-(iodomethyl)benzene

【CA登记号】

【 分 子 式 】C7H6FI

【 分 子 量 】236.0275132

【元素组成】C 35.62% H 2.56% F 8.05% I 53.77%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(X)

A synthesis for the 18F-labeled compound has also been reported. The piperazinylquinoxaline (IX) was obtained from chloroquinoxaline (VI) and excess piperazine (VIII) at 160 C. This was then alkylated with 4-[18F]fluorobenzyl iodide (X) in refluxing CH2Cl2 to provide the labeled product.

1 Katounina, T.; et al.; Synthesis and biological investigations of [18F]MR. Bioorg Med Chem 1998, 6, 6, 789.
2 Lancelot, J.-C.; Prunier, H.; Rault, S.; et al.; Novel and selective partial agonists of 5-HT3 rece. J Med Chem 1997, 40, 12, 1808.
3 Katounina, T.; et al.; Synthesis of [18F]MR 18445 and its in vivo evaluat. J Label Compd Radiopharm 1997, 40, 542.
4 Rault, S.; Lancelot, J.-C.; Prunier, H.; Robba, M.; Delagrange, P.; Renard, P.; Adam, G. (ADIR et Cie.); Pyrrolopyrazine derivs. with 5-HT3 activity. CA 2122890; EP 0623620; FR 2704547; JP 1994340666; US 5599812 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VI) 23597 4-chloropyrrolo[1,2-a]quinoxalin-7-yl methyl ether; 4-chloro-7-methoxypyrrolo[1,2-a]quinoxaline C12H9ClN2O 详情 详情
(VIII) 10355 Diethylenediamine; Piperazine 110-85-0 C4H10N2 详情 详情
(IX) 23600 7-methoxy-4-(1-piperazinyl)pyrrolo[1,2-a]quinoxaline; methyl 4-(1-piperazinyl)pyrrolo[1,2-a]quinoxalin-7-yl ether C16H18N4O 详情 详情
(X) 23601 1-fluoro-4-(iodomethyl)benzene C7H6FI 详情 详情
(X) 45316 1-fluoro-4-(iodomethyl)benzene C7H6FI 详情 详情
Extended Information