7-methoxy-4-(1-piperazinyl)pyrrolo[1,2-a]quinoxaline; methyl 4-(1-piperazinyl)pyrrolo[1,2-a]quinoxalin-7-yl ether -Drug Synthesis Database

【结构式】

【分子编号】23600

【品名】7-methoxy-4-(1-piperazinyl)pyrrolo[1,2-a]quinoxaline; methyl 4-(1-piperazinyl)pyrrolo[1,2-a]quinoxalin-7-yl ether

【CA登记号】

【分子式】C₁₆H₁₈N₄O

【分子量】282.34528

【元素组成】C 68.06% H 6.43% N 19.84% O 5.67%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IX)

A synthesis for the 18F-labeled compound has also been reported. The piperazinylquinoxaline (IX) was obtained from chloroquinoxaline (VI) and excess piperazine (VIII) at 160 C. This was then alkylated with 4-[18F]fluorobenzyl iodide (X) in refluxing CH2Cl2 to provide the labeled product.

参考文献中间体

合成目标

【1】 Katounina, T.; et al.; Synthesis and biological investigations of [18F]MR. Bioorg Med Chem 1998, 6, 6, 789.
【2】 Lancelot, J.-C.; Prunier, H.; Rault, S.; et al.; Novel and selective partial agonists of 5-HT3 rece. J Med Chem 1997, 40, 12, 1808.
【3】 Katounina, T.; et al.; Synthesis of [18F]MR 18445 and its in vivo evaluat. J Label Compd Radiopharm 1997, 40, 542.
【4】 Rault, S.; Lancelot, J.-C.; Prunier, H.; Robba, M.; Delagrange, P.; Renard, P.; Adam, G. (ADIR et Cie.); Pyrrolopyrazine derivs. with 5-HT3 activity. CA 2122890; EP 0623620; FR 2704547; JP 1994340666; US 5599812 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VI)	23597	4-chloropyrrolo[1,2-a]quinoxalin-7-yl methyl ether; 4-chloro-7-methoxypyrrolo[1,2-a]quinoxaline		C₁₂H₉ClN₂O	详情	详情
(VIII)	10355	Diethylenediamine; Piperazine	110-85-0	C₄H₁₀N₂	详情	详情
(IX)	23600	7-methoxy-4-(1-piperazinyl)pyrrolo[1,2-a]quinoxaline; methyl 4-(1-piperazinyl)pyrrolo[1,2-a]quinoxalin-7-yl ether		C₁₆H₁₈N₄O	详情	详情
(X)	23601	1-fluoro-4-(iodomethyl)benzene		C₇H₆FI	详情	详情
(X)	45316	1-fluoro-4-(iodomethyl)benzene		C₇H₆FI	详情	详情

Extended Information