【结 构 式】 |
【分子编号】45191 【品名】5-(difluoromethoxy)-1H-benzimidazole-2-thiol; 5-(difluoromethoxy)-1H-benzimidazol-2-ylhydrosulfide 【CA登记号】 |
【 分 子 式 】C8H6F2N2OS 【 分 子 量 】216.2113264 【元素组成】C 44.44% H 2.8% F 17.57% N 12.96% O 7.4% S 14.83% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)A new synthesis of [14C]-labeled pantoprazole has been described: The cyclization of potassium [14C]-ethylxanthate (I) with the diaminobenzene (II) by means of NaOH gives the imidazole (III), which is condensed with 2-(chloromethyl)-3,4-dimethoxypyridine (IV) by means of NaOH in ethanol to afford the sulfide (V). Finally, this compound is oxidized with m-chloroperbenzoic acid (mcpba) in dichloromethane.
【1】 Saunders, D.; Lawrie, K.W.M.; Crowe, A.M.; Johnston, C.E.A.; The synthesis of [14C]pantoprazole - SK&F 96022Z - An H+/K+ ATP inhibitor. J Label Compd Radiopharm 1992, 31, 5, 409. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 14032 | Dithiocarbonic acid O-ethyl ester potassium salt | C3H5KOS2 | 详情 | 详情 | |
(I) | 45190 | potassium 1-(carbodithioatooxy)ethane | C3H5KOS2 | 详情 | 详情 | |
(II) | 14033 | 4-(Difluoromethoxy)-1,2-benzenediamine; 2-Amino-4-(difluoromethoxy)phenylamine | C7H8F2N2O | 详情 | 详情 | |
(III) | 14034 | 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol; 5-(Difluoromethoxy)-1H-benzimidazol-2-ylhydrosulfide; 5-Difluoromethoxy-2-mercapto-1H-benzimidazole | 97963-62-7 | C8H6F2N2OS | 详情 | 详情 |
(III) | 45191 | 5-(difluoromethoxy)-1H-benzimidazole-2-thiol; 5-(difluoromethoxy)-1H-benzimidazol-2-ylhydrosulfide | C8H6F2N2OS | 详情 | 详情 | |
(IV) | 14035 | 2-(Chloromethyl)-3,4-dimethoxypyridine; 2-(Chloromethyl)-3-methoxy-4-pyridinyl methyl ether | 72830-09-2 | C8H10ClNO2 | 详情 | 详情 |
(V) | 14036 | 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfanyl]-1H-benzimidazole; 2-([[5-(Difluoromethoxy)-1H-benzimidazol-2-yl]sulfanyl]methyl)-3-methoxy-4-pyridinyl methyl ether | 102625-64-9 | C16H15F2N3O3S | 详情 | 详情 |
(V) | 45192 | 2-([[5-(difluoromethoxy)-1H-benzimidazol-2-yl]sulfanyl]methyl)-3-methoxy-4-pyridinyl methyl ether; 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfanyl]-1H-benzimidazole | C16H15F2N3O3S | 详情 | 详情 |
Extended Information