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【结 构 式】 
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【分子编号】45056 【品名】2-chloropyrimidine 【CA登记号】 |
【 分 子 式 】C4H3ClN2 【 分 子 量 】114.534 【元素组成】C 41.95% H 2.64% Cl 30.95% N 24.46% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The condensation of piperazine (I) with [14C]-labeled 2-chloropyrimidine (II) in refluxing ethanol gives the labeled 1-(2-pyrimidinyl)piperazine (III), which is then condensed with the N-(4-bromobutyl)imide (IV) by means of K2CO3 and KI as before, affording SM-3997 labeled at the pyrimidine ring.
| 【1】 Kanamaru, H.; Nishioka, K.; 14C-labeling of a novel anxiolytic agent tandospirone. J Label Compd Radiopharm 1992, 31, 6, 427. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10355 | Diethylenediamine; Piperazine | 110-85-0 | C4H10N2 | 详情 | 详情 |
| (II) | 11191 | 2-Chloropyrimidine | 1722-12-9 | C4H3ClN2 | 详情 | 详情 |
| (II) | 45056 | 2-chloropyrimidine | C4H3ClN2 | 详情 | 详情 | |
| (III) | 11175 | 2-(1-Piperazinyl)pyrimidine; 2-Piperazinopyrimidine; N-(Pyrimidinyl)piperazine | 20980-22-7 | C8H12N4 | 详情 | 详情 |
| (III) | 45057 | 2-(1-piperazinyl)pyrimidine | C8H12N4 | 详情 | 详情 | |
| (IV) | 11174 | (1R,2S,6R,7S)-4-(4-Bromobutyl)-4-azatricyclo[5.2.1.0(2,6)]decane-3,5-dione | C13H18BrNO2 | 详情 | 详情 |
Extended Information