2-(1-piperazinyl)pyrimidine -Drug Synthesis Database

【结构式】

【分子编号】45057

【品名】2-(1-piperazinyl)pyrimidine

【CA登记号】

【分子式】C₈H₁₂N₄

【分子量】164.21024

【元素组成】C 58.52% H 7.37% N 34.12%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of piperazine (I) with [14C]-labeled 2-chloropyrimidine (II) in refluxing ethanol gives the labeled 1-(2-pyrimidinyl)piperazine (III), which is then condensed with the N-(4-bromobutyl)imide (IV) by means of K2CO3 and KI as before, affording SM-3997 labeled at the pyrimidine ring.

参考文献中间体

合成目标

【1】 Kanamaru, H.; Nishioka, K.; 14C-labeling of a novel anxiolytic agent tandospirone. J Label Compd Radiopharm 1992, 31, 6, 427.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10355	Diethylenediamine; Piperazine	110-85-0	C₄H₁₀N₂	详情	详情
(II)	11191	2-Chloropyrimidine	1722-12-9	C₄H₃ClN₂	详情	详情
(II)	45056	2-chloropyrimidine		C₄H₃ClN₂	详情	详情
(III)	11175	2-(1-Piperazinyl)pyrimidine; 2-Piperazinopyrimidine; N-(Pyrimidinyl)piperazine	20980-22-7	C₈H₁₂N₄	详情	详情
(III)	45057	2-(1-piperazinyl)pyrimidine		C₈H₁₂N₄	详情	详情
(IV)	11174	(1R,2S,6R,7S)-4-(4-Bromobutyl)-4-azatricyclo[5.2.1.0(2,6)]decane-3,5-dione		C₁₃H₁₈BrNO₂	详情	详情

Extended Information