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【结 构 式】

【分子编号】51332

【品名】tert-butyl 2-[(heptylamino)oxy]-2-oxoethylcarbamate

【CA登记号】

【 分 子 式 】C14H28N2O4

【 分 子 量 】288.3874

【元素组成】C 58.31% H 9.79% N 9.71% O 22.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Condensation of N-heptylhydroxylamine (I) with the protected glycine succinimidyl ester (II) produced the O-acyl intermediate (III), which spontaneously rearranged to the N-acyl analogue (IV). Then, cleavage of the amino protecting group of (IV) furnished the title N-hydroxy glycinamide.

1 Pietra, C.; Delcanale, M.; Merlini, L.; Bergamaschi, M.; Ventura, P.; Servadio, V.; Villetti, G.; Redenti, E.; Ghidini, E.; Synthesis of a new series of N-hydroxy, N-alkylamides of aminoacids as ligands of NMDA glycine site. Eur J Med Chem 1999, 34, 9, 711.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 51331 N-heptylhydroxylamine; 1-(hydroxyamino)heptane C7H17NO 详情 详情
(II) 16364 tert-butyl N-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]carbamate; N-T-BOC-glycine N-hydroxysuccinimide ester 3392-07-2 C11H16N2O6 详情 详情
(III) 51332 tert-butyl 2-[(heptylamino)oxy]-2-oxoethylcarbamate C14H28N2O4 详情 详情
(IV) 51333 tert-butyl 2-[heptyl(hydroxy)amino]-2-oxoethylcarbamate C14H28N2O4 详情 详情
Extended Information