tert-butyl 2-[(heptylamino)oxy]-2-oxoethylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】51332

【品名】tert-butyl 2-[(heptylamino)oxy]-2-oxoethylcarbamate

【CA登记号】

【分子式】C₁₄H₂₈N₂O₄

【分子量】288.3874

【元素组成】C 58.31% H 9.79% N 9.71% O 22.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Condensation of N-heptylhydroxylamine (I) with the protected glycine succinimidyl ester (II) produced the O-acyl intermediate (III), which spontaneously rearranged to the N-acyl analogue (IV). Then, cleavage of the amino protecting group of (IV) furnished the title N-hydroxy glycinamide.

参考文献中间体

合成目标

【1】 Pietra, C.; Delcanale, M.; Merlini, L.; Bergamaschi, M.; Ventura, P.; Servadio, V.; Villetti, G.; Redenti, E.; Ghidini, E.; Synthesis of a new series of N-hydroxy, N-alkylamides of aminoacids as ligands of NMDA glycine site. Eur J Med Chem 1999, 34, 9, 711.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	51331	N-heptylhydroxylamine; 1-(hydroxyamino)heptane		C₇H₁₇NO	详情	详情
(II)	16364	tert-butyl N-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]carbamate; N-T-BOC-glycine N-hydroxysuccinimide ester	3392-07-2	C₁₁H₁₆N₂O₆	详情	详情
(III)	51332	tert-butyl 2-[(heptylamino)oxy]-2-oxoethylcarbamate		C₁₄H₂₈N₂O₄	详情	详情
(IV)	51333	tert-butyl 2-[heptyl(hydroxy)amino]-2-oxoethylcarbamate		C₁₄H₂₈N₂O₄	详情	详情

Extended Information