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【结 构 式】 
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【药物名称】 【化学名称】2-Amino-N-heptylacetohydroxamic acid 【CA登记号】 【 分 子 式 】C9H20N2O2 【 分 子 量 】188.27195 |
【开发单位】Chiesi (Originator) 【药理作用】Antiepileptic Drugs, Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, NMDA Glycine-Site Antagonists |
合成路线1
Condensation of N-heptylhydroxylamine (I) with the protected glycine succinimidyl ester (II) produced the O-acyl intermediate (III), which spontaneously rearranged to the N-acyl analogue (IV). Then, cleavage of the amino protecting group of (IV) furnished the title N-hydroxy glycinamide.
| 【1】 Pietra, C.; Delcanale, M.; Merlini, L.; Bergamaschi, M.; Ventura, P.; Servadio, V.; Villetti, G.; Redenti, E.; Ghidini, E.; Synthesis of a new series of N-hydroxy, N-alkylamides of aminoacids as ligands of NMDA glycine site. Eur J Med Chem 1999, 34, 9, 711. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51331 | N-heptylhydroxylamine; 1-(hydroxyamino)heptane | C7H17NO | 详情 | 详情 | |
| (II) | 16364 | tert-butyl N-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]carbamate; N-T-BOC-glycine N-hydroxysuccinimide ester | 3392-07-2 | C11H16N2O6 | 详情 | 详情 |
| (III) | 51332 | tert-butyl 2-[(heptylamino)oxy]-2-oxoethylcarbamate | C14H28N2O4 | 详情 | 详情 | |
| (IV) | 51333 | tert-butyl 2-[heptyl(hydroxy)amino]-2-oxoethylcarbamate | C14H28N2O4 | 详情 | 详情 |
Extended Information