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【结 构 式】

【分子编号】44582

【品名】N-methyl-1-naphthamide

【CA登记号】

【 分 子 式 】C12H11NO

【 分 子 量 】185.22548

【元素组成】C 77.81% H 5.99% N 7.56% O 8.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

1) The Grignard reaction of 1-bromonaphthalene (I) with Mg in THF and then with [14C]-labeled CO2 gives the corresponding 1-naphthoic acid (II), which by reaction with SO2Cl2 and then with methylamine yields [14C]-N-methyl-1-naphthalenecarboxamide (III). The reduction of (III) with LiAlH4 in refluxing THF affords the corresponding amine (IV). Finally, this compound is condensed with 1-bromo-6,6-dimethylhept-2-en-4-yne (V) by means of Na2CO3 in DMF, and treated with ethanolic HCl.

1 Andres, H.; Carbon-14 labelling of terbinafine, an antimycotic agent. J Label Compd Radiopharm 1989, 27, 11, 1307.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10105 1-Bromonaphthalene 90-11-9 C10H7Br 详情 详情
(II) 10106 1-Naphthoic acid 86-55-5 C11H8O2 详情 详情
(II) 44581 1-naphthoic acid C11H8O2 详情 详情
(III) 10107 N-Methyl-1-naphthamide 3400-33-7 C12H11NO 详情 详情
(III) 44582 N-methyl-1-naphthamide C12H11NO 详情 详情
(IV) 10108 N-Methyl(1-naphthyl)methanamine; N-Methyl-N-(1-naphthylmethyl)amine; 1-Methyl-1-naphthalenemethylamine 65473-13-4 C12H13N 详情 详情
(IV) 44583 N-methyl(1-naphthyl)methanamine; N-methyl-N-(1-naphthylmethyl)amine C12H13N 详情 详情
(V) 10109 (E)-1-Bromo-6,6-dimethyl-2-hepten-4-yne 78629-21-7 C9H13Br 详情 详情
Extended Information