【结 构 式】 |
【分子编号】10107 【品名】N-Methyl-1-naphthamide 【CA登记号】3400-33-7 |
【 分 子 式 】C12H11NO 【 分 子 量 】185.22548 【元素组成】C 77.81% H 5.99% N 7.56% O 8.64% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)1) The Grignard reaction of 1-bromonaphthalene (I) with Mg in THF and then with [14C]-labeled CO2 gives the corresponding 1-naphthoic acid (II), which by reaction with SO2Cl2 and then with methylamine yields [14C]-N-methyl-1-naphthalenecarboxamide (III). The reduction of (III) with LiAlH4 in refluxing THF affords the corresponding amine (IV). Finally, this compound is condensed with 1-bromo-6,6-dimethylhept-2-en-4-yne (V) by means of Na2CO3 in DMF, and treated with ethanolic HCl.
【1】 Andres, H.; Carbon-14 labelling of terbinafine, an antimycotic agent. J Label Compd Radiopharm 1989, 27, 11, 1307. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 10105 | 1-Bromonaphthalene | 90-11-9 | C10H7Br | 详情 | 详情 |
(II) | 10106 | 1-Naphthoic acid | 86-55-5 | C11H8O2 | 详情 | 详情 |
(II) | 44581 | 1-naphthoic acid | C11H8O2 | 详情 | 详情 | |
(III) | 10107 | N-Methyl-1-naphthamide | 3400-33-7 | C12H11NO | 详情 | 详情 |
(III) | 44582 | N-methyl-1-naphthamide | C12H11NO | 详情 | 详情 | |
(IV) | 10108 | N-Methyl(1-naphthyl)methanamine; N-Methyl-N-(1-naphthylmethyl)amine; 1-Methyl-1-naphthalenemethylamine | 65473-13-4 | C12H13N | 详情 | 详情 |
(IV) | 44583 | N-methyl(1-naphthyl)methanamine; N-methyl-N-(1-naphthylmethyl)amine | C12H13N | 详情 | 详情 | |
(V) | 10109 | (E)-1-Bromo-6,6-dimethyl-2-hepten-4-yne | 78629-21-7 | C9H13Br | 详情 | 详情 |
Extended Information