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【结 构 式】

【分子编号】44570

【品名】 

【CA登记号】

【 分 子 式 】C11H9FN2O3

【 分 子 量 】236.2025432

【元素组成】C 55.94% H 3.84% F 8.04% N 11.86% O 20.32%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The synthesis of [2H]-, [3H]- and [14C]-radiolabeled sorbinil has been described: [2H]- and [3H]-sorbinil are prepared by chlorination of sorbinil (I) with Cl2 and FeCl2 in dry DMF to give the 8-chloro derivative (II), which is then reduced with deuterium or tritium over Pd/C in ethanol. [14C]-Labeled sorbinil is prepared by cyclization of 6-fluoro-3,4-dihydro-2H-benzo[b]pyran-4-one (III) with [14C]-potassium cyanide and ammonium carbonate in hot ethanol-water to give radiolabeled racemic sorbinil, which is then submitted to optical resolution with brucine in ethanol.

1 Howard, H.R.; Sarges, R.; Evans, M.; Synthesis of H-2-labelled, H-3-labelled and C-14-labelled CP-45,634 (sorbinil). J Label Compd Radiopharm 1991, 29, 6, 703.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10054 (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione 68367-52-2 C11H9FN2O3 详情 详情
(II) 10055 (S)-8-Chloro-6-fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione C11H8ClFN2O3 详情 详情
(III) 10056 6-Fluoro-2,3-dihydro-4H-chromen-4-one; 6-Fluoro-4-chromanone 66892-34-0 C9H7FO2 详情 详情
(IV) 10057 6-Fluorospiro[chroman-4,4'-imidazolidine]-2',4'-dione 69684-83-9 C11H9FN2O3 详情 详情
(IV) 44570   C11H9FN2O3 详情 详情
Extended Information