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【结 构 式】 
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【分子编号】10055 【品名】(S)-8-Chloro-6-fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione 【CA登记号】 |
【 分 子 式 】C11H8ClFN2O3 【 分 子 量 】270.6473032 【元素组成】C 48.82% H 2.98% Cl 13.1% F 7.02% N 10.35% O 17.73% |
合成路线1
该中间体在本合成路线中的序号：(II)The synthesis of [2H]-, [3H]- and [14C]-radiolabeled sorbinil has been described: [2H]- and [3H]-sorbinil are prepared by chlorination of sorbinil (I) with Cl2 and FeCl2 in dry DMF to give the 8-chloro derivative (II), which is then reduced with deuterium or tritium over Pd/C in ethanol. [14C]-Labeled sorbinil is prepared by cyclization of 6-fluoro-3,4-dihydro-2H-benzo[b]pyran-4-one (III) with [14C]-potassium cyanide and ammonium carbonate in hot ethanol-water to give radiolabeled racemic sorbinil, which is then submitted to optical resolution with brucine in ethanol.
| 【1】 Howard, H.R.; Sarges, R.; Evans, M.; Synthesis of H-2-labelled, H-3-labelled and C-14-labelled CP-45,634 (sorbinil). J Label Compd Radiopharm 1991, 29, 6, 703. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10054 | (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione | 68367-52-2 | C11H9FN2O3 | 详情 | 详情 |
| (II) | 10055 | (S)-8-Chloro-6-fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione | C11H8ClFN2O3 | 详情 | 详情 | |
| (III) | 10056 | 6-Fluoro-2,3-dihydro-4H-chromen-4-one; 6-Fluoro-4-chromanone | 66892-34-0 | C9H7FO2 | 详情 | 详情 |
| (IV) | 10057 | 6-Fluorospiro[chroman-4,4'-imidazolidine]-2',4'-dione | 69684-83-9 | C11H9FN2O3 | 详情 | 详情 |
| (IV) | 44570 | C11H9FN2O3 | 详情 | 详情 |