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【结 构 式】 
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【分子编号】44564 【品名】potassium acetate 【CA登记号】127-08-2 |
【 分 子 式 】C2H3KO2 【 分 子 量 】98.14292 【元素组成】C 24.48% H 3.08% K 39.84% O 32.6% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)The synthesis of [14C]-mitoguazone has been reported: The methylation of [14C]-labeled potassium acetate (I) with dimethyl sulfate in HMPT gives the corresponding ester (II), which by reaction with the sodium salt of dimethylsulfoxide (III) in DMSO affords the hemithioketal (IV). Finally, this compound is condensed with aminoguanidine (V) in DMSO/water.
| 【1】 Burgos, A.; Ellames, G.J.; Convenient synthesis of [2-C-14]-methylglyoxal bis(guanylhydrazone), [C-14]-mitoguazone. J Label Compd Radiopharm 1995, 36, 1, 93. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 44564 | potassium acetate | 127-08-2 | C2H3KO2 | 详情 | 详情 |
| (I) | 44565 | potassium acetate | C2H3KO2 | 详情 | 详情 | |
| (II) | 44566 | methyl acetate | 79-20-9 | C3H6O2 | 详情 | 详情 |
| (II) | 44567 | methyl acetate | C3H6O2 | 详情 | 详情 | |
| (III) | 44569 | [(methoxysulfanyl)methyl]sodium | C2H5NaOS | 详情 | 详情 | |
| (IV) | 10014 | 1-Hydroxy-1-(methylsulfanyl)acetone | 74178-33-9 | C4H8O2S | 详情 | 详情 |
| (IV) | 44568 | 1-Hydroxy-1-(methylsulfanyl)acetone | C4H8O2S | 详情 | 详情 | |
| (V) | 10015 | 1-Hydrazinecarboximidamide; Hydrazinecarboximidamide | 79-17-4 | CH6N4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)The described compound can be obtained by treatment of carboxaldehyde (I) with potassium acetate (II) and acetic anhydride.
| 【1】 Cheng, C.Y.; Silvestrini, B. (Angelini Pharmaceuticals Inc.); 3-Substd. 1-benzyl-1H-indazole derivs. as antifertility agents. US 6001865 . |
Extended Information