4-[(tert-butoxycarbonyl)amino]-2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl; tert-butyl 2'-[(tert-butylamino)sulfonyl][1,1'-biphenyl]-4-ylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】44128

【品名】4-[(tert-butoxycarbonyl)amino]-2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl; tert-butyl 2'-[(tert-butylamino)sulfonyl][1,1'-biphenyl]-4-ylcarbamate

【CA登记号】

【分子式】C₂₁H₂₈N₂O₄S

【分子量】404.5304

【元素组成】C 62.35% H 6.98% N 6.92% O 15.82% S 7.93%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The intermediate biphenylamine (IV) was prepared by Suzuki coupling of N-Boc-4-bromoaniline (I) with 2-(N-tert-butylaminosulfonyl)phenylboronic acid (II), followed by deprotection of the Boc group.

参考文献中间体

合成目标

【1】 Galemmo, R.A. Jr.; Fevig, J.; Lam, P.Y.; et al.; New functional groups for interaction with the S1 pocket of factor Xa: The discovery of 1-(4-methoxyphenyl)pyrazole inhibitors. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 290.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	26633	tert-butyl 4-bromophenylcarbamate	C₁₁H₁₄BrNO₂	详情	详情
(II)	26627	2-[(tert-butylamino)sulfonyl]phenylboronic acid	C₁₀H₁₆BNO₄S	详情	详情
(III)	44128	4-[(tert-butoxycarbonyl)amino]-2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl; tert-butyl 2'-[(tert-butylamino)sulfonyl][1,1'-biphenyl]-4-ylcarbamate	C₂₁H₂₈N₂O₄S	详情	详情
(IV)	23363	4'-amino-N-(tert-butyl)[1,1'-biphenyl]-2-sulfonamide	C₁₆H₂₀N₂O₂S	详情	详情

Extended Information