1-(3,3-diphenylpropyl)-1,4-diazepane -Drug Synthesis Database

【结构式】

【分子编号】43553

【品名】1-(3,3-diphenylpropyl)-1,4-diazepane

【CA登记号】

【分子式】C₂₀H₂₆N₂

【分子量】294.43992

【元素组成】C 81.59% H 8.9% N 9.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Reaction of 3,3-diphenylpropylmethanesulfonate (I) with homopiperazine hydrochloride (II) and NaI in ethanol provides compound (III), which is finally condensed with 4-(methylsulfonyl)benzyl bromide by means of K2CO3 in acetonitrile or by means of NaI in ethanol.

参考文献中间体

合成目标

【1】 Shiota, T.; et al.; Chemokine receptor antagonistic activities and structure-activity relationship of novel homopiperazine derivatives. 19th Symp Med Chem and 8th Annu Meet Div Med Chem Jpn (Nov 17-19, Tokyo) 1999, Abst 1P-10.
【2】 Shiota, T.; Yamagami, S.; Kataoka, K.; Endo, N.; Tanaka, H.; Barnum, D.; Greene, J.; Moree, W.; Ramirez-Weinhouse, M.; Tarby, C. (Teijin Ltd.); Diarylalkyl cyclic diamine derivs. as chemokine receptor antagonists. EP 0914319; JP 1997309877; WO 9744329 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	43552	(3,3-diphenylpropoxy)(methyl)dimethylene-lambda(6)-sulfane		C₁₈H₂₂OS	详情	详情
(II)	25030	1,4-diazepane	505-66-8	C₅H₁₂N₂	详情	详情
(III)	43553	1-(3,3-diphenylpropyl)-1,4-diazepane		C₂₀H₂₆N₂	详情	详情
(IV)	43554	4-(bromomethyl)phenyl methyl sulfone; [4-(bromomethyl)phenyl](methyl)dioxo-lambda(6)-sulfane	53606-06-7	C₈H₉BrO₂S	详情	详情

Extended Information